Prague, October 10, 2023

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8:30 – 9:05    Registration
9:05 – 9:15    Opening


9:15 – 12:45        SESSION I 

chairs: Kateřina Rohlenová and Jan Trka

Nick van Gastel (UCLouvain, Belgium)
Metabolic dependencies and interactions in the leukemic bone marrow niche

Kateřina Hložková (CLIP, Second Faculty of Medicine, Charles University, Prague)     abstract
L-asparaginase by-product glutamate impedes the effect of chemotherapy by augmenting glutathione biosynthesis

Petra Hyroššová (Institute of Biotechnology, CAS, Prague)     abstract
Pyrimidine de novo synthesis in endothelial cells: an overlooked target?

10:45 – 11:15     Coffee break

Tomáš Büchler (Motol University Hospital, Prague)    
Cancer metabolism as a treatment target

Dominik Musil (Institute of Organic Chemistry and Biochemistry, CAS, Prague)       abstract
Targeting myeloid cells and modulation of their function by fully synthetic antibody mimetics

Petr Heneberg (Third Faculty of Medicine, Charles University, Prague)     abstract
Extracellular nicotinamide is dispensable for ovarian cancer cell proliferation

Pavel Burda (Institute of Hematology and Blood Transfusion, Prague)     abstract
Imatinib therapy of chronic myeloid leukemia significantly reduced carnitine intake resulting in adverse event - impaired muscle cell metabolism

12:45 – 13:30     Lunch

13:30 – 14:15    Moderated Poster walk
chairs: Júlia Starková, Nick van Gastel, Jakub Rohlena

14:20 – 16:25    SESSION II

chairs: Tomáš Mráček and Jan Frič

Jakub Rohlena (Institute of Biotechnology, CAS, Prague)     abstract
Canonical de novo synthesis of aspartate is dispensable for tumor growth

Marcela Hortová – Kohoutková (FNUSA-ICRC, Brno)     abstract
CaN-NFAT controls immunometabolic reprogramming of human monocytes and contributes to i mmunoparalysis in sepsis

Katarína Smolková (IPHYS CAS, Prague)     abstract
Mitochondrial bcaa metabolism in pancreatic cancer facilitates mitochondrial import of fatty acids

15:15 – 15:45    Coffee break

Cristian Sandoval-Acuña (Institute of Biotechnology, CAS, Prague)     abstract
Simultaneous iron chelation and ferroptosis induction as a novel anticancer strategy

Marek Jedlička (Institute of Hematology and Blood Transfusion, Prague)     abstract
Glutaminase – HIF1α axis in regulation of NK cell cytototoxicity

Jaromír Gumulec (Dept. of Pathological Physiology, Faculty of Medicine, MU, Brno)     abstract
Unraveling the Metabolic Transformation and Biomechanical Shifts Driving Cancer Progression

Stjepan Uldrijan (Faculty of Medicine, Masaryk University, Brno)     abstract
New insights into AMPK activity control in malignant melanoma

16:25 – 16:30    Closing

18:00 – 23:00    Social Event

13:30 - 14:15    POSTER SESSION

(chronological order)

Kamila Baslarová     abstract
Metabolic changes in breast cancer cells resistant to tamoxifen

Anna Dorotíková     abstract
The effect of amino acid deprivation on the growth signaling in malignant melanoma

Vojtěch Charvát     abstract
ER-stress as a tool to influence protein arginine methyltransferases in primary clear cell renal carcinomas and nontransformed renal cells

Karolína Janoušková     abstract
Modeling genetic aberrations present in relapsed all by crispr/cas9 and their metabolic profile

Lucie Janstová     abstract
Bone marrow assembloids – an ultimate three-dimensional model to study hemato-oncologic dissorders

Matúš Kolárik     abstract
Role of SLC7A11 in L-asparaginase therapy response in acute lymphoblastic leukemia

Kateřina Koždoňová     abstract
The essential role of LAMTOR1 in the control of AMPK activity in BRAF-mutated melanoma cells

Kateřina Kuželová     abstract
Cell metabolic phenotype and immune escape in acute myeloid leukemia Ioanna Papatheodorou Uncovering the interplay between the metabolic and the functional status of innate immune cells

Markéta Pimková Polidarová      abstract
STING Agonists Induce Robust Cytokine Secretion And Rapid Monocyte Cell Death in Peripheral Blood Mononuclear Cells

Jan Trnka     abstract
Accurate, flexible and low-cost method for normalizing Seahorse XF data to cell number


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