8:30 – 9:05 Registration
9:05 – 9:15 Opening
9:15 – 12:45 SESSION I
chairs: Kateřina Rohlenová and Jan Trka
9:15
Nick van Gastel (UCLouvain, Belgium)
Metabolic dependencies and interactions in the leukemic bone marrow niche
10:00
Kateřina Hložková (CLIP, Second Faculty of Medicine, Charles University, Prague)
abstract
L-asparaginase by-product glutamate impedes the effect of chemotherapy by augmenting glutathione biosynthesis
10:25
Petra Hyroššová (Institute of Biotechnology, CAS, Prague)
abstract
Pyrimidine de novo synthesis in endothelial cells: an overlooked target?
10:45 – 11:15 Coffee break
11:15
Tomáš Büchler (Motol University Hospital, Prague)
Cancer metabolism as a treatment target
11:45
Dominik Musil (Institute of Organic Chemistry and Biochemistry, CAS, Prague)
abstract
Targeting myeloid cells and modulation of their function by fully synthetic antibody mimetics
12:05
Petr Heneberg (Third Faculty of Medicine, Charles University, Prague)
abstract
Extracellular nicotinamide is dispensable for ovarian cancer cell proliferation
12:25
Pavel Burda (Institute of Hematology and Blood Transfusion, Prague)
abstract
Imatinib therapy of chronic myeloid leukemia significantly reduced carnitine intake resulting in adverse event - impaired muscle cell metabolism
12:45 – 13:30 Lunch
13:30 – 14:15 Moderated Poster walk
chairs: Júlia Starková, Nick van Gastel, Jakub Rohlena
14:20 – 16:25 SESSION II
chairs: Tomáš Mráček and Jan Frič
14:20
Jakub Rohlena (Institute of Biotechnology, CAS, Prague)
abstract
Canonical de novo synthesis of aspartate is dispensable for tumor growth
14:45
Marcela Hortová – Kohoutková (FNUSA-ICRC, Brno)
abstract
CaN-NFAT controls immunometabolic reprogramming of human monocytes and contributes to i mmunoparalysis in sepsis
15:05
Katarína Smolková (IPHYS CAS, Prague)
abstract
Mitochondrial bcaa metabolism in pancreatic cancer facilitates mitochondrial import of fatty acids
15:15 – 15:45 Coffee break
15:45
Cristian Sandoval-Acuña (Institute of Biotechnology, CAS, Prague)
abstract
Simultaneous iron chelation and ferroptosis induction as a novel anticancer strategy
15:55
Marek Jedlička (Institute of Hematology and Blood Transfusion, Prague)
abstract
Glutaminase – HIF1α axis in regulation of NK cell cytototoxicity
16:05
Jaromír Gumulec (Dept. of Pathological Physiology, Faculty of Medicine, MU, Brno)
abstract
Unraveling the Metabolic Transformation and Biomechanical Shifts Driving Cancer Progression
16:15
Stjepan Uldrijan (Faculty of Medicine, Masaryk University, Brno)
abstract
New insights into AMPK activity control in malignant melanoma
16:25 – 16:30 Closing
18:00 – 23:00 Social Event
13:30 - 14:15 POSTER SESSION
(chronological order)
Kamila Baslarová
abstract
Metabolic changes in breast cancer cells resistant to tamoxifen
Anna Dorotíková
abstract
The effect of amino acid deprivation on the growth signaling in malignant melanoma
Vojtěch Charvát
abstract
ER-stress as a tool to influence protein arginine methyltransferases in primary clear cell renal carcinomas and nontransformed renal cells
Karolína Janoušková
abstract
Modeling genetic aberrations present in relapsed all by crispr/cas9 and their metabolic profile
Lucie Janstová
abstract
Bone marrow assembloids – an ultimate three-dimensional model to study hemato-oncologic dissorders
Matúš Kolárik
abstract
Role of SLC7A11 in L-asparaginase therapy response in acute lymphoblastic leukemia
Kateřina Koždoňová
abstract
The essential role of LAMTOR1 in the control of AMPK activity in BRAF-mutated melanoma cells
Kateřina Kuželová
abstract
Cell metabolic phenotype and immune escape in acute myeloid leukemia Ioanna Papatheodorou Uncovering the interplay between the metabolic and the functional status of innate immune cells
Markéta Pimková Polidarová
abstract
STING Agonists Induce Robust Cytokine Secretion And Rapid Monocyte Cell Death in Peripheral Blood Mononuclear Cells
Jan Trnka
abstract
Accurate, flexible and low-cost method for normalizing Seahorse XF data to cell number